Razieh Salahandish
Assistant Professor
Department:
Electrical Engineering & Computer Science
Phone Number: +1 (416) 736 2100 - Extension 44323
Email: raziehs@yorku.ca
Website: https://lab-ha.eecs.yorku.ca/
Bio
Razieh (Neda) Salahandish obtained her Ph.D. in electrochemistry in 2018, with her doctoral research focus on the synthesis and fabrication of nano-structure-based biosensors for early-stage ultra-sensitive detection of Breast Cancer. Prior to joining the Lassonde School of Engineering, she has been a post-doctoral fellow (2019-2022) at the University of Calgary, Department of Biomedical Engineering, developing in-vitro diagnostic (IVD) platforms for clinical early diagnosis of various disease biomarkers, including quantitative rapid detection of COVID-19. Currently an Assistant Professor at the Department of Electrical Engineering and Computer Science at York University, she leads interdisciplinary research revolving around the development of miniaturized electrical and electrochemical sensors, integrated microfluidics systems, smart organ-on-chip platforms, and wearable medical devices. As an entrepreneurially minded scholar, she co-founded Criticare Dx in 2018, a start-up company in the field of medical device development. She has also been an academic collaborator with a variety of early-stage ventures in the advanced sensing field, such as CardiAI Inc and Selective Lab, enthusiastically pursuing her translational research.
Research Interests
• Microfluidics and Point-of-Care Diagnostics
• Wearable Platforms for Disease Monitoring
• Medical Devices
• Biosensors for the Detection of Disease-Related Biomarkers
• Biosensing Integrated into Organ-on-a-Chip Platforms
• In-Vivo Monitoring of Inflammatory, Cancer, and Brain Injury Biomarkers using CMOS and Junction-Gate Field-Effect Transistor (JFET) Technologies
Selected Publications
Patents
• R. Koul, R. Salahandish, et. al., (Filed in September 2019, Reviewed and Accepted in September 2020). “PORTABLE ELECTROCHEMICAL-SENSOR SYSTEM FOR ANALYZING USER’S HEALTH CONDITIONS AND METHOD THEREOF” (US Patent No. CA3060849A1). U.S. Patent and Trademark Office.
• A. Sanati-Nezhad, R. Salahandish, H. Zargartalebi, “APPARATUS, SYSTEMS, AND METHODS FOR
REPRODUCIBLE AND SCALABLE GENERATION OF SINGLE OR MULTILAYER NANOMATERIAL CONSTRUCTS”, (Filed PAT89769W-90, July 2019).
• R. Salahandish, A. Sanati-Nezhad, S. Khetani, F. Haghayegh, “SELF-POWERED CAPILLARY MICROFLUIDIC-BASED ELECTROCHEMICAL BIOSENSING DEVICES, SYSTEMS, AND METHODS”, (Filed US provisional Patent No. 63/262,018, October 2021).
• S. Shajari, A. Sanati-Nezhad, R. Salahandish, et. Al., “DEVELOPMENT OF WEARABLE STRESS BIOSENSOR DEVICE”, (Filed 63/229,216, February 2022).
Selected Journal Papers
• R. Salahandish, F. Haghayegh, G. Ayala-Charca, J. Hyun, M. Khalghollah, A. Zare, B. Far, B. M. Berenger, Y. Dong Niu, E. Ghafar-Zadeh, A. Sanati-Nezhad, “Bi-ECDAQ: An electrochemical dual-immuno-biosensor accompanied by a customized bi potentiostat for clinical detection of SARS-CoV-2 Nucleocapsid proteins”, Biosensors and Bioelectronics (2022).
• S. Shajari, R. Salahandish, A. Zare, M. Hassani, S. Moossavi, E. Munro, D. Rosenegger, J. S. Bains, A. Sanati Nezhad, “MicroSweat: a wearable, universal and flexible microfluidic patch for noninvasive and reliable sweat collection enabling human stress level monitoring”, (2022, Accepted, Advanced Science).
• R. Salahandish, P. Jalali, H. Tabrizi Osouli, J. Hyun, F. Haghayegh, A. Zare, M. Khalghollah, E. Ghafar-Zadeh, A. Sanati-Nezhad, “A Compact, Low-Cost, and Binary Sensing (BiSense) Platform for Noise-Free and Self-Validated Impedimetric Detection of COVID-19 Infected Patients”, (Biosensors and Bioelectronics (2022).
• R. Salahandish ‡, F. Haghayegh ‡, S. Khetani, M. Hasani, A. Sanati-Nezhad, “Immuno-affinity Potent Strip with Pre-Embedded Intermixed PEDOT:PSS Conductive Polymers and Graphene Nanosheets for Bio-Ready Electrochemical Biosensing of Central Nervous System Injury Biomarkers”, ACS Applied Materials & Interfaces (2022).
• R. Salahandish, M. Hasani, A. Zare, F. Haghayegh, A. Sanati-Nezhad, “Autonomous electrochemical biosensing of glial fibrillary acidic protein for point-of-care detection of central nervous system injuries”, Lab-on-a-Chip (2022).
• G. Ayala-Charca, R. Salahandish, M. Khalghollah, D. Sadighbayan, F. Haghayegh, A. SanatiNezhad, E. Ghafar-Zadeh, “A Low-cost Handheld Impedimetric Biosensing System for Rapid Diagnostics of SARS-CoV-2 Infections”, IEEE Sensors (2022).
• F. Haghayegh, R. Salahandish, M. Hasani, A. Sanati-Nezhad, “Highly stable buffer-based zincoxide/reduced graphene-oxide nano-surface chemistry for rapid immunosensing of SARS-CoV- 2 antigens”, ACS Applied Materials & Interfaces (2022).
• F. Haghayegh ‡, R. Salahandish ‡, A. Zare, M. Khalghollah, A. Sanati-Nezhad, “Immuno-biosensor on a chip: a self-powered microfluidic-based electrochemical biosensing platform for point-of care quantification of proteins”, Lab-on-a-chip (2022).
• R. Salahandish, A. Ghaffarinejad, E. Omidinia, H. Zargartalebi, K. Majidzadeh-A, Seyed M. Naghib, A. Sanati-Nezhad, ‘‘Label-free ultrasensitive detection of breast cancer miRNA-21 biomarker employing electrochemical nano-genosensor based on sandwiched AgNPs in PANI and N-doped graphene”, Biosensors and Bioelectronics (2018).
• R. Salahandish, A. Ghaffarinejad, Seyed M. Naghib, K. Majidzadeh-A, H. Zargartalebi, A. SanatiNezhad, ‘‘Nano-biosensor for highly sensitive detection of HER2 positive breast cancer”,
Biosensors and Bioelectronics (2018).
• R. Salahandish, A. Ghaffarinejad, S.M. Naghib, K. Majidzadeh-A, A. Sanati-Nezhad, ‘‘A Novel Graphene-Grafted Gold Nanoparticles Composite for Highly Sensitive Electrochemical Biosensing”. IEEE Sensors Journal (2018).
• R. Salahandish, A. Ghaffarinejad, S.M. Naghib, A. Niyazi, K. Majidzadeh-A, M. Janmaleki, A. Sanati-Nezhad, ‘‘Sandwich-structured nanoparticles-grafted functionalized graphene-based 3D nanocomposites for high-performance biosensors to detect ascorbic acid biomolecule’’, Nature Scientific Reports (2019).
• R. Salahandish, H. Zargartalebi, M. Janmaleki, S. Khetani, M. Azarmanesh, M. Mohammadi Ashani, R. Aburashed, M. Vatani, A. Ghaffarinejad, A. Sanati‐Nezhad. ‘‘Reproducible and Scalable Generation of Multilayer Nanocomposite Constructs for Ultrasensitive Nanobiosensing’’, Advanced Materials Technologies (2019).
• A. Sabahi, R. Salahandish, A. Ghaffarinejad, E. Omidinia, ‘‘Development of an electrochemical nano-genosensor for serum miR-21 based on SWCNT-grafted dendritic Au nanostructure for early detection of prostate cancer”, Talanta (2018)
Recent Projects
o Design and development of automated home-based electrochemical assessment kits for detection of COVID-19 virus, and associated overexpressed protein (SARS-CoV-2 Nucleocapsid protein)
o Design and development of smart capsules as the gastrointestinal microbiome explorer for non-invasive sampling of gut microbiome inside the small intestine, and in
situ detection of the inflammatory biomarkers via the embedded wireless complementary metal-oxide-semiconductor (CMOS) nanochip
o Microfluidic-based electrochemical sensing of Brain injury Biomarkers such as GFAP
o Exosome isolation and detection by the development of paper-based microfluidic chips integrated with electrochemical sensors
o Design and Development of Electrochemical biosensors for wearable diagnostics
o Design of multi-electrode strips and the read-out setup
o Development of multi-purpose microchannels coatings for droplet microfluidics, tissue engineering, and organ-on-chip systems
o Synthesize sensitive nanocomposites as a substrate of biosensor
o Development of novel screen-printing inks for the Fabrication of Highly Sensitive Electrochemical Screen-Printed Electrodes
Work Experience
August 2018 – Present
Co-Founder and Senior Scientist
Criticare Dx, Calgary, Alberta, Canada https://www.criticaredx.ca/
• Head of Electrochemical sensor Research & Development Division
• Microfluidic Diagnostics Production Management
• Design and development of electrodes for electrochemical applications
March 2022 – Present
Scientific/Technical Product Developer, R&D Collaboration with Industry
Canary Global Inc, Toronto, Ontario, Canada https://www.canarydetect.com/
• Responsible for all stages of the product development cycle from conceptual design to final product fabrication
• Design for scalable manufacturing and clinical evaluations
• Design and implement clinical experiments
• Effective marketing and scientific communication
August 2019 – June 2020
Electrochemical Biosensor Product Manager
CardiAI Inc., Calgary, Alberta, Canada https://cardiai.com/
• Design & development of electrochemical biosensors for detection of SARS-CoV-2 RNA, and heart failure biomarker (NT-Pro BNP) proteins
• Head researcher at the electrochemical sensing and microfluidics division
• Design and fabrication of bi-potentiostat as an impedimetry readout setup for the point-of-care platforms